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Formyl Peptide Receptor agonists for myocardial infarction

Myocardial infarction (MI or “heart attack”) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention. However,...

Published: 11/15/2016 | Inventor(s): Rebecca Ritchie

Keywords(s):

Category(s): Cardiovascular disease, Therapeutic, Target

Plasmalogen modulation for atherosclerosis

Atherosclerosis is the single most common cause of cardiovascular disease and is the major contributor to the development of angina, heart attacks, congestive heart failure, peripheral vascular disease and stroke. Despite the introduction of statin based therapy to reduce levels of plasma LDL-cholesterol, the epidemic of cardiovascular disease claims...

Published: 11/15/2016 | Inventor(s): Peter Meikle

Keywords(s):

Category(s): Cardiovascular disease, Therapeutic, Target

CD40L-Mac1 binding inhibitor for Inflammation

Atherosclerosis is a chronic, inflammatory disease driven by the continuous emigration of monocytes into the vessel wall. CD40L is an established marker and mediator of chronic inflammatory diseases such as atherosclerosis. While anti-CD40L treatment generated promising results in clinical trials, elevated thrombembolic complications prohibited the...

Published: 3/4/2019 | Inventor(s): Karlheinz Peter, Denis Wolf, Andreas Zirlik

Keywords(s):

Category(s): Target, Cardiovascular disease, Therapeutic